NAIP

Name

NLR family apoptosis inhibitory protein

Type

protein-coding

Position

70,968,166–71,025,339 (−)

Aliases

BIRC1, NLRB1, psiNAIP

Ensembl

ENSG00000249437

RefSeq RNA

NM_001346870.2, NM_004536.3, NM_022892.2, XM_047443278.1, XM_047443279.1

RefSeq protein

NP_001333799.1, NP_004527.2, NP_075043.1, XP_047299234.1, XP_047299235.1

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016].

via MyGene.info

Gene · Ensembl

NLR family apoptosis inhibitory protein

Symbol

NAIP

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR5_2_CTG1_1:385,732-442,341

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0