NLRP4
Sign in to saveAlso known as CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.
Gene data
NLRP4- Name
- NLR family pyrin domain containing 4
- Type
- protein-coding
- Position
- 55,836,540–55,881,855 (+)
- Aliases
- CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
- Ensembl
- ENSG00000160505
- RefSeq RNA
- NM_134444.5, XM_017026344.1, XM_017026345.1, XM_054319920.1, XM_054319921.1
- RefSeq protein
- NP_604393.2, XP_016881833.1, XP_016881834.1, XP_054175895.1, XP_054175896.1
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016].
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
NLR family pyrin domain containing 4
- Symbol
- NLRP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:55,836,540-55,881,855
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- exact match
- identifiers.org/ncbigene/147945
- HomoloGene ID
- 75315
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 19
- genomic start
- 55836540
- genomic end
- 55881855
- cytogenetic location
- 19q13.43
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.
Excerpted from Wikipedia’s “NLRP4” article, available under the CC BY-SA 4.0 licence.