NLRP6
Sign in to saveAlso known as AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.
Gene data
NLRP6- Name
- NLR family pyrin domain containing 6
- Type
- protein-coding
- Aliases
- AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
via MyGene.info
Gene · Ensembl
NLR family pyrin domain containing 6
- Symbol
- NLRP6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:278,407-286,691
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.
==References==
Excerpted from Wikipedia’s “NLRP6” article, available under the CC BY-SA 4.0 licence.