NLRP8
Sign in to saveAlso known as CLR19.2, NALP8, NOD16, PAN4, NLR family, pyrin domain containing 8, NLR family pyrin domain containing 8
NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals. It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.
Gene data
NLRP8- Name
- NLR family pyrin domain containing 8
- Type
- protein-coding
- Aliases
- CLR19.2, NALP8, NOD16, PAN4
This gene encodes a member of the nucleotide-binding oligomerization domain/ leucine rich repeat/ pyrin domain containing (NLRP) subfamily, which belongs to the Nod-like receptor family of proteins. NLRP genes play roles in the mammalian innate immune system through inflammasome formation and activation of caspases. In addition, NLRP genes have been found to function during mammalian reproduction. Consistent with a function during human preimplantation development, this gene is expressed at high levels in oocytes with decreased levels in embryos. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
via MyGene.info
Gene · Ensembl
NLR family pyrin domain containing 8
- Symbol
- NLRP8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:55,947,832-55,981,158
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 82360
- exact match
- identifiers.org/ncbigene/126205
- genomic end
- 56499995
- genomic start
- 56459198
- cytogenetic location
- 19q13.43
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals. It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.
==References==