Bcl-xL
Sign in to savethumb|X-ray crystal structure of Bcl-xL with 1.76 Å resolution
~3 min read
Article
4 sectionsContents
- Function
- Clinical significance
- Related proteins
- References
thumb|X-ray crystal structure of Bcl-xL with 1.76 Å resolution
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of mitochondrial contents such as cytochrome c, which leads to caspase activation and ultimately, programmed cell death.
Connections
signal transduction
Entity
mitochondrion
Entity
digital object identifier
Entity
Q180686
Entity
apoptotic process
Entity
bibcode
Entity
Q229883
Entity
signaling receptor
Entity
tumor protein p53
Protein
polycythemia vera
Entity
tumor necrosis factor
Protein
doxorubicin
Entity
quercetin
Entity
ligand
Entity
cytochrome c, somatic
Protein
caspase
Entity
Q411114
Entity
BCL2 apoptosis regulator
Protein
CASP3
Gene
fisetin
Entity