senolytics
Sign in to saveAlso known as senolytic, Senotherapeutics
A senolytic (from the words senescence and -lytic, "decomposition or breakdown") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.
Research
2,641 papers- Cellular senescence and senolytics: the path to the clinic.Nature medicine · 2022
- Targeting cellular senescence with senotherapeutics: senolytics and senomorphics.The FEBS journal · 2023
- The Role of Senolytics in Osteoporosis.Biomolecules · 2025
- Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions.Biomolecules · 2025
- The potential of Senolytics in transplantation.Mechanisms of ageing and development · 2021
via PubMed
~5 min read
Article
6 sectionsContents
- Research
- Senolytic candidates
- Senomorphics
- See also
- References
- Further reading
A senolytic (from the words senescence and -lytic, "decomposition or breakdown") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.
A related concept is "senostatic", which means to suppress senescence.