glutaminase
Sign in to saveAlso known as KGA, GDPAG, AAD20, L-glutaminase, IPR015868, CASGID, glutamine aminohydrolase
Glutaminase (, glutaminase I, L-glutaminase, glutamine aminohydrolase) is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells.
Key facts
- Enzyme.Name
- glutaminase
- Enzyme.EC_number
- 3.5.1.2
- Enzyme.CAS_number
- 9001-47-2
- Enzyme.GO_code
- 0004359
- Enzyme.image
- Glutaminase.png
- Enzyme.caption
- Crystallographic structure of dimeric protein-glutaminase from Chryseobacterium proteolyticum.
- Protein family.Symbol
- Glutaminase
- Protein family.Name
- Glutaminase
- Protein family.image
- PDB 2osu EBI.jpg
- Protein family.caption
- probable glutaminase from bacillus subtilis complexed with 6-diazo-5-oxo-ʟ-norleucine
- Protein family.Pfam
- PF04960
- Protein family.Pfam_clan
- CL0013
- Protein family.InterPro
- IPR015868
- Protein family.SCOP
- 1mki
- Protein.Name
- glutaminase 2(liver)
- Protein.HGNCid
- 29570
- Protein.Symbol
- GLS2
- Protein.EntrezGene
- 27165
via Wikipedia infobox
Research
4,410 papers- Glutaminase 2 as a therapeutic target in glioblastoma.Biochimica et biophysica acta. Reviews on cancer · 2024
- The role of glutaminase in cancer.Histopathology · 2020
- Glutaminase isoenzymes in the metabolic therapy of cancer.Biochimica et biophysica acta. Reviews on cancer · 2018
- Glutaminase inhibition as potential cancer therapeutics: current status and future applications.Journal of enzyme inhibition and medicinal chemistry · 2024
- Targeting glutaminase to starve lymphoma cells.Haematologica · 2023
via PubMed
Wikidata facts
Show 10 more facts
- Commons category
- Glutaminase
- EC enzyme number
- 3.5.1.2
- HomoloGene ID
- 22726
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2744
- genomic end
- 191830278
- genomic start
- 190880821
- chromosome
- human chromosome 2
- cytogenetic location
- 2q32.2
- expressed in
- postcentral gyrus
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Tissue distribution
- Regulation
- Structure
- Isozymes
- Related proteins
- Clinical significance
- References
- External links
Glutaminase (, glutaminase I, L-glutaminase, glutamine aminohydrolase) is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells.
Glutaminase catalyzes the following reaction: Glutamine + → glutamate +
Excerpted from Wikipedia’s “glutaminase” article, available under the CC BY-SA 4.0 licence.