aspartate transaminase
Sign in to saveAlso known as aspartate aminotransferase, aspartate aminotransferases, AST, SGOT, GOT, OT
class of enzymes
Key facts
- Ec no
- 2.6.1.1
- Cas no
- 9000-97-9
- Intenz
- IntEnz view
- Brenda
- BRENDA entry
- Expasy
- NiceZyme view
- Kegg
- KEGG entry
- Metacyc
- metabolic pathway
- Priam
- profile
- Pdb structures
- RCSB PDB PDBe PDBsum
- Gene ontology
- AmiGO / QuickGO
- Pmc
- articles
- Pubmed
- articles
- Ncbi
- proteins
via Wikipedia infobox
Wikidata facts
- Subclass of
- transaminase
- Image
- Aspartate transaminase.png
Show 2 more facts
- EC enzyme number
- 2.6.1.1
- Commons category
- Aspartate transaminases
Sources (2)
via Wikidata · CC0
~10 min read
Encyclopedic overview
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954. AST catalyzes the reversible transfer of an α-amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. AST is found in the liver, heart, skeletal muscle, kidneys, brain, red blood cells and gall bladder. Serum AST level, serum ALT (alanine transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.
The half-life of total AST in the circulation approximates 17 hours and, on average, 87 hours for mitochondrial AST. Aminotransferase is cleared by sinusoidal cells in the liver.
Excerpted from Wikipedia’s “aspartate transaminase” article, available under the CC BY-SA 4.0 licence.