Also known as cystathionine gamma-lyase, CSE, CGL
protein-coding gene in the species Homo sapiens
Gene data
CTH- Name
- cystathionine gamma-lyase
- Type
- protein-coding
- Position
- 70,406,194–70,442,771 (+)
- Aliases
- CGL, CSE
- Ensembl
- ENSG00000116761
- RefSeq RNA
- NM_001190463.2, NM_001902.6, NM_153742.5, XM_017000416.3, XM_054334636.1
- RefSeq protein
- NP_001177392.1, NP_001893.2, NP_714964.2, XP_016855905.1, XP_054190611.1
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
Glycine, serine and threonine metabolism - Homo sapiens (human)Cysteine and methionine metabolism - Homo sapiens (human)Selenocompound metabolism - Homo sapiens (human)MetabolismMetabolismDegradation of cysteine and homocysteineCysteine formation from homocysteineSulfur amino acid metabolismMetabolism of ingested SeMet, Sec, MeSec into H2SeSelenoamino acid metabolism
via MyGene.info
Gene · Ensembl
cystathionine gamma-lyase
- Symbol
- CTH
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:70,406,194-70,443,519
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 2nmp.jpg
Show 5 more facts
- HomoloGene ID
- 1432
- exact match
- identifiers.org/ncbigene/1491
- genomic end
- 70905534
- genomic start
- 70876901
- cytogenetic location
- 1p31.1
Sources (9)
via Wikidata · CC0
Available in 6 languages
via Wikidata sitelinks · CC0
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