Structure via PubChem · Public domain (PubChem)
folitixorin
Sign in to saveAlso known as 5,10-Methylenetetrahydrofolate
5,10-Methylenetetrahydrofolate (N5,N10-Methylenetetrahydrofolate; 5,10-CH2-THF) is cofactor in several biochemical reactions. It exists in nature as the diastereoisomer [6R]-5,10-methylene-THF.
In the Vinony graph
Within Vinony's link graph, folitixorin is referenced by 70 other articles, and connects out to levomefolic acid, cofactor and folinic acid.
It is catalogued under topics including Coenzymes and Folates.
Its subject is documented across 15 Wikipedia language editions.
Chemical data
- Formula
- C20H23N7O6
- Molecular weight
- 457.4 g/mol
- IUPAC name
- (2S)-2-[[4-(3-amino-1-oxo-4,5,6,6a,7,9-hexahydroimidazo[1,5-f]pteridin-8-yl)benzoyl]amino]pentanedioic acid
- SMILES
- C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- InChIKey
- QYNUQALWYRSVHF-ABLWVSNPSA-N
- XLogP
- -0.5
- Polar surface area
- 190 Ų
- H-bond donors
- 6
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 457.171
Show 4 more facts
- canonical SMILES
- C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)NC(CCC(=O)O)C(=O)O
- chemical formula
- C₂₀H₂₃N₇O₆
- isomeric SMILES
- C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- Commons category
- 5,10-Methylenetetrahydrofolate
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Selected functions
- Formaldehyde equivalent
- Pyrimidine biosynthesis
- Biomodulator
- See also
- References
5,10-Methylenetetrahydrofolate (N5,N10-Methylenetetrahydrofolate; 5,10-CH2-THF) is cofactor in several biochemical reactions. It exists in nature as the diastereoisomer [6R]-5,10-methylene-THF.
As an intermediate in one-carbon metabolism, 5,10-CH2-THF converts to 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and methenyltetrahydrofolate. It is substrate for the enzyme methylenetetrahydrofolate reductase (MTHFR), which gives 5-methyltetrahydrofolate. It is mainly produced by the reaction of tetrahydrofolate with serine, catalyzed by the enzyme serine hydroxymethyltransferase.
Excerpted from Wikipedia’s “folitixorin” article, available under the CC BY-SA 4.0 licence.