Senolíticos
Sign in to saveAlso known as senolytic, Senotherapeutics
A senolytic (from the words senescence and -lytic, "decomposition or breakdown") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.
In the Vinony graph
Vinony's link graph records 45 inbound references to Senolíticos, and connects out to heat shock protein Hsp90 family, cancer and pH.
It sits within the topics Anti-aging substances, Senescence and Senescence in non-human organisms.
Vinony links it to 10 Wikipedia language editions.
Research
2,641 papers- Cellular senescence and senolytics: the path to the clinic.Nature medicine · 2022
- Targeting cellular senescence with senotherapeutics: senolytics and senomorphics.The FEBS journal · 2023
- The Role of Senolytics in Osteoporosis.Biomolecules · 2025
- Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions.Biomolecules · 2025
- The potential of Senolytics in transplantation.Mechanisms of ageing and development · 2021
via PubMed
Article · Español
Los senolíticos son fármacos que inducen selectivamente la muerte de células senescentes. Las células senescentes son aquellas que han dejado de dividirse. Se acumulan en cuerpos envejecidos y aceleran el proceso de envejecimiento. Experimentos en ratones han demostrado que la eliminación de las células senescentes retrasa la edad de aparición de enfermedades. Las células senescentes son similares a las células cancerígenas en cuanto tienen incrementada la expresión de las llamadas redes de genes pro-supervivencia, que las ayudan a resistir la apoptosis (muerte celular programada). En ratones, el mayor efecto antienvejecimiento se consiguió con una combinación de dos compuestos senolíticos.
Abstract from DBpedia / Wikipedia · CC BY-SA