ZBP1
Sign in to saveAlso known as C20orf183, DAI, DLM-1, DLM1, Z-DNA binding protein 1
Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is an intracellular protein in mammals that can activate an innate immune pathways to suppress the viral infection. ZENB1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA, which are pathogen-associated molecular patterns (PAMPs). It associates with Receptor Interacting Protein Kinase 3 (RIPK3) to initiate PANoptosis, a form of inflammatory programmed cell death.
Gene data
ZBP1- Name
- Z-DNA binding protein 1
- Type
- protein-coding
- Aliases
- C20orf183, DAI, DLM-1, DLM1
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
via MyGene.info
Gene · Ensembl
Z-DNA binding protein 1
- Symbol
- ZBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:57,603,575-57,620,576
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 10972
- exact match
- identifiers.org/ncbigene/81030
- genomic start
- 56178902
- genomic end
- 56195632
- cytogenetic location
- 20q13.31
Sources (4)
via Wikidata · CC0
~6 min read
Article
6 sectionsContents
- History
- Structure
- Function and role in disease
- Z-DNA and Z-RNA binding
- References
- Further reading
Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is an intracellular protein in mammals that can activate an innate immune pathways to suppress the viral infection. ZENB1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA, which are pathogen-associated molecular patterns (PAMPs). It associates with Receptor Interacting Protein Kinase 3 (RIPK3) to initiate PANoptosis, a form of inflammatory programmed cell death.
During infection of human cells with influenza A virus (IAV) and HSV-1, host cell-derived Z-RNAs, arising from viral disruption of host transcription termination, are detected by ZBP1 to initiate NF-κB signalling and PANoptosis.