NAB2

Also known as MADER, NGFI-A binding protein 2

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.

Gene data

NAB2

Name: NGFI-A binding protein 2
Type: protein-coding
Position: 57,089,014–57,095,476 (+)
Aliases: MADER
Ensembl: ENSG00000166886
RefSeq RNA: NM_001330305.2, NM_005967.4
RefSeq protein: NP_001317234.1, NP_005958.1

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase III negative regulation of DNA-templated transcription

Molecular function

transcription coregulator activity transcription coregulator activity transcription corepressor activity protein binding identical protein binding

Cellular component

nucleus nucleus nucleoplasm

Pathways

Developmental Biology Signal Transduction Signal Transduction Signaling by NTRKs Signaling by NTRKs Signaling by NTRK1 (TRKA)Signaling by NTRK1 (TRKA)Nuclear Events (kinase and transcription factor activation)Nuclear Events (kinase and transcription factor activation)Signaling by Receptor Tyrosine Kinases

via MyGene.info

Gene · Ensembl

NGFI-A binding protein 2

Symbol: NAB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:57,088,883-57,095,476
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 4353
exact match: identifiers.org/ncbigene/4665
genomic end: 57489259
genomic start: 57089043
cytogenetic location: 12q13.3

Sources (4)

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Contents

Function
Pathology
References
Further reading

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.

==Function==