AGAP2
Sign in to saveAlso known as CENTG1, GGAP2, PIKE, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.
In the Vinony graph
Within Vinony's link graph, AGAP2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 12.
Its subject is documented across 8 Wikipedia language editions.
Gene data
AGAP2- Name
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
- Type
- protein-coding
- Position
- 57,723,761–57,742,209 (−)
- Aliases
- CENTG1, GGAP2, PIKE
- Ensembl
- ENSG00000135439
- RefSeq RNA
- NM_001122772.3, NM_014770.4, XM_005268625.4, XM_005268626.3, XM_054371030.1
- RefSeq protein
- NP_001116244.1, NP_055585.1, XP_005268682.1, XP_005268683.1, XP_054227005.1
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
- Symbol
- AGAP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:57,723,761-57,742,209
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CENTG1 PDB 2bmj.png
Show 8 more facts
- HomoloGene ID
- 86815
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/116986
- chromosome
- human chromosome 12
- genomic start
- 58118980
- genomic end
- 58135940
- cytogenetic location
- 12q14.1
- expressed in
- putamen
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- External links
- Further reading
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.
== Interactions == CENTG1 has been shown to interact with: EPB41L1, HOMER1 and PIK3R1.
Excerpted from Wikipedia’s “AGAP2” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0