ASAP2

Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Type

protein-coding

Aliases

AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

via MyGene.info

Gene · Ensembl

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Symbol

ASAP2

Biotype

Protein coding

Organism

Homo sapiens

Location

2:9,206,602-9,405,683

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein DDEF2 PDB 1dcq.png

via Wikidata · CC0