ABL2

Also known as ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.

Gene data

ABL2

Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Type: protein-coding
Position: 179,099,330–179,229,684 (−)
Aliases: ABLL, ARG
Ensembl: ENSG00000143322
RefSeq RNA: NM_001136000.3, NM_001136001.2, NM_001168236.2, NM_001168237.2, NM_001168238.2
RefSeq protein: NP_001129472.1, NP_001129473.1, NP_001161708.1, NP_001161709.1, NP_001161710.1

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009].