ABL2
Sign in to saveAlso known as ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase
Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.
In the Vinony graph
Within Vinony's link graph, ABL2 is referenced by 109 other articles, and connects out to PubMed, Ensembl genome database project and ABL proto-oncogene 1, non-receptor tyrosine kinase.
It sits within the topics Genes on human chromosome 1, Oncogenes and Tyrosine kinases.
Its subject is documented across 5 Wikipedia language editions.
Gene data
ABL2- Name
- ABL proto-oncogene 2, non-receptor tyrosine kinase
- Type
- protein-coding
- Position
- 179,099,330–179,229,684 (−)
- Aliases
- ABLL, ARG
- Ensembl
- ENSG00000143322
- RefSeq RNA
- NM_001136000.3, NM_001136001.2, NM_001168236.2, NM_001168237.2, NM_001168238.2
- RefSeq protein
- NP_001129472.1, NP_001129473.1, NP_001161708.1, NP_001161709.1, NP_001161710.1
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ABL proto-oncogene 2, non-receptor tyrosine kinase
- Symbol
- ABL2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:179,099,330-179,229,684
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ABL2 PDB 1ab2.png
Show 9 more facts
- HomoloGene ID
- 5278
- found in taxon
- Homo sapiens
- genetic association
- allergy
- exact match
- identifiers.org/ncbigene/27
- genomic end
- 179198819
- genomic start
- 179099330
- chromosome
- human chromosome 1
- cytogenetic location
- 1q25.2
- expressed in
- cerebellar vermis
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.
== Function ==
Excerpted from Wikipedia’s “ABL2” article, available under the CC BY-SA 4.0 licence.