CLEC7A
Sign in to saveAlso known as BGR, CANDF4, CLECSF12, DECTIN1, CD369, SCARE2, C-type lectin domain family 7 member A, C-type lectin domain containing 7A
C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is fo
Gene data
CLEC7A- Name
- C-type lectin domain containing 7A
- Type
- protein-coding
- Position
- 10,116,777–10,130,258 (−)
- Aliases
- BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
- Ensembl
- ENSG00000172243
- RefSeq RNA
- NM_022570.5, NM_197947.3, NM_197948.3, NM_197949.3, NM_197950.3
- RefSeq protein
- NP_072092.2, NP_922938.1, NP_922939.1, NP_922940.1, NP_922941.1
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
C-type lectin domain containing 7A
- Symbol
- CLEC7A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:10,116,766-10,130,269
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 49606
- exact match
- identifiers.org/ncbigene/64581
- genomic end
- 10282857
- genomic start
- 10269376
- cytogenetic location
- 12p13.2
Sources (3)
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Structure
- Function
- Antifungal immunity
- Co-stimulatory molecule
- References
- External links
- Further reading
C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
== Structure == Dectin-1 is a transmembrane protein containing an immunoreceptor tyrosine-based activation (ITAM)-like motif in its intracellular tail (which is involved in cellular activation) and one C-type lectin-like domain (carbohydrate-recognition domain, CRD) in the extracellular region (which recognizes β-glucans and endogenous ligands on T cells). The CRD is separated from the membrane by a stalk region. CLEC7A contains putative sites of N-linked glycosylation in the stalk region.