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GeneQ14907275· pop 13· linked from 290 articles

IL22

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Also known as IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18

protein-coding gene in the species Homo sapiens

Gene data

IL22

Name: interleukin 22
Type: protein-coding
Position: 68,248,242–68,253,604 (−)
Aliases: IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18
Ensembl: ENSG00000127318
RefSeq RNA: NM_020525.5
RefSeq protein: NP_065386.1

This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021].

Gene Ontology

Biological process

acute-phase response inflammatory response signal transduction negative regulation of inflammatory response negative regulation of inflammatory response negative regulation of inflammatory response response to glucocorticoid

Molecular function

cytokine activity cytokine activity protein binding interleukin-22 receptor binding

Cellular component

extracellular region extracellular region extracellular region extracellular region extracellular region

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)JAK-STAT signaling pathway - Homo sapiens (human)Th17 cell differentiation - Homo sapiens (human)Inflammatory bowel disease - Homo sapiens (human)Cytokine Signaling in Immune system Disease Immune System Signaling by Interleukins Diseases of signal transduction by growth factor receptors and second messengers Interleukin-20 family signaling

via MyGene.info

Gene · Ensembl

interleukin 22

Symbol: IL22
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:68,248,242-68,253,604
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: IL22 IL22R 3DGC.png

Show 6 more facts

HomoloGene ID: 9669
exact match: identifiers.org/ncbigene/50616
genomic end: 68253604
genomic start: 68642022
cytogenetic location: 12q15
Commons category: Interleukin-22 (IL-22)

Sources (6)

via Wikidata · CC0

Available in 12 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 12 Interleukins