VCAN

Also known as CSPG2, ERVR, GHAP, PG-M, WGN, WGN1, versican

Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.

Gene data

VCAN

Name: versican
Type: protein-coding
Aliases: CSPG2, ERVR, GHAP, PG-M, WGN, WGN1

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].

via MyGene.info

Gene · Ensembl

versican

Symbol: VCAN
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:83,471,618-83,585,130
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 3228
exact match: identifiers.org/ncbigene/1462
genomic start: 83471618
genomic end: 82878122
cytogenetic location: 5q14.2-q14.3

Sources (8)

via Wikidata · CC0

~8 min read

Article

13 sections

Contents

Structure
Function
N-terminus
Glycosaminoglycan binding region
C-terminus
Clinical significance
Cancer and metastasis
Lung disorders
Skin disorders
Interactions
References
Further reading
External links

Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.

Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan. They designated it versican in recognition of its versatile modular structure.