DCN

Also known as DC, DSPG2, PG40, PGII, PGS2, SLRR1B, mDcn

Decorin is a protein that in humans is encoded by the DCN gene.

Gene data

DCN

Name: decorin
Type: protein-coding
Position: 91,140,484–91,183,217 (−)
Aliases: CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Ensembl: ENSG00000011465
RefSeq RNA: NM_001920.5, NM_133503.4, NM_133504.3, NM_133505.3, NM_133506.3
RefSeq protein: NP_001911.1, NP_598010.1, NP_598011.1, NP_598012.1, NP_598013.1

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].

Gene Ontology

Biological process

Article

8 sections

Contents

Naming
Function
Clinical significance
Animal studies
Interactions
References
Further reading
External links

Decorin is a protein that in humans is encoded by the DCN gene.

Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS).