aggrecan
Sign in to saveAlso known as aggrecan core protein, ACAN, Chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, chondroitin sulfate proteoglycan core protein 1, CSPCP, cartilage-specific proteoglycan core protein, aggrecans
Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.
Protein · UniProt
Aggrecan core protein
- Gene
- ACAN
- Organism
- Homo sapiens (Human)
- Length
- 2,530 aa
- Molecular mass
- 261,329 Da
- Evidence
- 1: Evidence at protein level
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region
Swiss-Prot (reviewed) · via UniProt
Research
7,746 papers- Aggrecan: Approaches to Study Biophysical and Biomechanical Properties.Methods in molecular biology (Clifton, N.J.) · 2022
- Aggrecan in Cardiovascular Development and Disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
- Aggrecan and versican: two brothers close or apart.American journal of physiology. Cell physiology · 2022
- Aggrecan: Beyond cartilage and into the brain.The international journal of biochemistry & cell biology · 2012
- [Aggrecan].Nihon rinsho. Japanese journal of clinical medicine · 2005
via PubMed
Clinical Trials
3 registered- PHASE2ACTIVE_NOT_RECRUITINGVosoritide for Selected Genetic Causes of Short StatureAndrew Dauber · NCT04219007
- UNKNOWNPotential Diagnostic Biomarkers for Aortic Dissection in the Emergency DepartmentChinese University of Hong Kong · NCT06065306
- PHASE1/PHASE2COMPLETEDGrowth Hormone Treatment in Patients With Aggrecan (ACAN) DeficiencyChildren's Hospital Medical Center, Cincinnati · NCT03288103
~5 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Function
- Clinical significance
- References
- Further reading
- External links
Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.
Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing. Aggrecan was named for its ability to form large aggregates in the cartilage tissue (a large aggregating proteoglycan).
Excerpted from Wikipedia’s “aggrecan” article, available under the CC BY-SA 4.0 licence.