CA19-9

Also known as CA 19-9, carbohydrate antigen 19-9, cancer antigen 19-9, sialylated Lewis (a) antigen, Carbohydrate antigen 19-9, CA-19-9 Antigen, alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc, NeuAcalpha2,3Galbeta1-3[Fucalpha1-4]GlcNAc

Carbohydrate antigen 19-9 (CA19-9), also known as sialyl-LewisA, is a tetrasaccharide which is usually attached to O-glycans on the surface of cells. It is known to play a role in cell-to-cell recognition processes. It is also a tumor marker used primarily in the management of pancreatic cancer.

In the Vinony graph

Within Vinony's link graph, CA19-9 is referenced by 66 other articles, and connects out to Colorectal cancer, lymphoma and false positives and false negatives.

It is catalogued under topics including Acetamides, Amino sugars and Chembox image size set.

Its subject is documented across 18 Wikipedia language editions.

Chemical data

Formula: C31H52N2O23
Molecular weight: 820.7 g/mol
IUPAC name: (2S,4S,5R,6R)-5-acetamido-2-[(2R,3R,4S,5S,6R)-2-[(3R,4R,5S,6R)-3-acetamido-2-hydroxy-6-(hydroxymethyl)-5-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
SMILES: C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H](OC([C@@H]([C@H]2O[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O[C@@]4(C[C@@H]([C@H]([C@@H](O4)[C@@H]([C@@H](CO)O)O)NC(=O)C)O)C(=O)O)O)NC(=O)C)O)CO)O)O)O
InChIKey: XBSNXOHQOTUENA-KRAHZTDDSA-N
XLogP: -8.3
Polar surface area: 403 Å²
H-bond donors: 15
H-bond acceptors: 23
Formal charge: 0

via PubChem

Research

9,811 papers

CA19-9 and CEA biosensors in pancreatic cancer.Clinica chimica acta; international journal of clinical chemistry · 2024
CA 19-9: Biochemical and Clinical Aspects.Advances in experimental medicine and biology · 2015
Monitoring Ca19-9 during pancreatic cyst surveillance: Better safe than sorry?United European gastroenterology journal · 2023
CA19-9: the Italian experience.Pancreas · 1994
[CA19-9: more than just a biomarker?].Zeitschrift fur Gastroenterologie · 2020

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 820.296

Show 4 more facts

isomeric SMILES: C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H](OC([C@@H]([C@H]2O[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O[C@@]4(C[C@@H]([C@H]([C@@H](O4)[C@@H]([C@@H](CO)O)O)NC(=O)C)O)C(=O)O)O)NC(=O)C)O)CO)O)O)O
canonical SMILES: CC1C(C(C(C(O1)OC2C(OC(C(C2OC3C(C(C(C(O3)CO)O)OC4(CC(C(C(O4)C(C(CO)O)O)NC(=O)C)O)C(=O)O)O)NC(=O)C)O)CO)O)O)O
chemical formula: C₃₁H₅₂N₂O₂₃
subject has role: tumor markers

Sources (3)

via Wikidata · CC0

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