SPINK1

Also known as PCTT, PSTI, Spink3, TATI, TCP, serine peptidase inhibitor, Kazal type 1, serine peptidase inhibitor Kazal type 1

Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.

Gene data

SPINK1

Name: serine peptidase inhibitor Kazal type 1
Type: protein-coding
Position: 147,824,572–147,831,671 (−)
Aliases: PCTT, PSTI, Spink3, TATI, TCP
Ensembl: ENSG00000164266
RefSeq RNA: NM_001354966.2, NM_001379610.1, NM_003122.5, XM_047417625.1, XM_047417626.1
RefSeq protein: NP_001341895.1, NP_001366539.1, NP_003113.2, XP_047273581.1, XP_047273582.1

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008].

Gene Ontology

Molecular function

endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity

~1 min read

Article

3 sections

Contents

See also
References
Further reading

Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.