SGK1
Sign in to saveAlso known as SGK, serum/glucocorticoid regulated kinase 1
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.
Gene data
SGK1- Name
- serum/glucocorticoid regulated kinase 1
- Type
- protein-coding
- Position
- 134,169,248–134,318,117 (−)
- Aliases
- SGK
- Ensembl
- ENSG00000118515
- RefSeq RNA
- NM_001143676.3, NM_001143677.2, NM_001143678.2, NM_001291995.2, NM_005627.4
- RefSeq protein
- NP_001137148.1, NP_001137149.1, NP_001137150.1, NP_001278924.1, NP_005618.2
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
serum/glucocorticoid regulated kinase 1
- Symbol
- SGK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:134,169,248-134,318,117
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~13 min read
Encyclopedic overview
19 sectionsContents
- Function
- Ion channel and transporter regulation
- Regulation of cell volume
- Dehydration
- Cell proliferation and apoptosis
- Memory formation
- Long-term potentiation
- Transcription
- Metabolism
- Kidney
- Gastrointestinal
- Cardiovascular
- Clinical significance
- Role in neuronal disease
- Huntingtin
- Other neuronal diseases
- Interactions
- References
- External links
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene.
SGK1 belongs to a subfamily of serine/threonine kinases that is under acute transcriptional control by several stimuli, including serum and glucocorticoids. The kinase is activated by insulin and growth factors via phosphatidylinositide-3-kinase, phosphoinositide-dependent protein kinase PDPK1 and mammalian target of rapamycin mTORC2. It has been shown to "regulate several enzymes and transcription factors; SGK1 contributes to the regulation of transport, hormone release, neuroexcitability, inflammation, cell proliferation and apoptosis". SGK1 increases the protein abundance and/or activity of a variety of ion channel, carriers, and the Na+/K+-ATPase. Over the past few years, there has been increasing evidence that SGK1 expression is regulated during both discrete developmental stages and pathological conditions such as hypertension, diabetic neuropathy, ischemia, trauma, and neurodegenerative diseases.
Excerpted from Wikipedia’s “SGK1” article, available under the CC BY-SA 4.0 licence.