SERPINA4

Also known as KAL, KLST, KST, PI-4, PI4, kallistatin, serpin family A member 4

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene.

In the Vinony graph

Vinony's link graph records 34 inbound references to SERPINA4, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 14 and Serine protease inhibitors.

Vinony links it to 6 Wikipedia language editions.

Gene data

SERPINA4

Name: serpin family A member 4
Type: protein-coding
Position: 94,561,390–94,570,995 (+)
Aliases: KAL, KLST, KST, PI-4, PI4, kallistatin
Ensembl: ENSG00000100665
RefSeq RNA: NM_001289032.2, NM_001289033.2, NM_006215.4
RefSeq protein: NP_001275961.1, NP_001275962.1, NP_006206.2

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular exosome. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular function

serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity protein binding

Cellular component

extracellular region extracellular region extracellular region extracellular region platelet dense granule lumen extracellular exosome

Pathways

Hemostasis Platelet degranulation Developmental Biology Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+Developmental Cell Lineages Developmental Cell Lineages of the Exocrine Pancreas Developmental Lineage of Pancreatic Acinar Cells

via MyGene.info

Gene · Ensembl

serpin family A member 4

Symbol: SERPINA4
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:94,561,390-94,570,995
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 48412
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/5267
genomic end: 95036250
genomic start: 94561442
chromosome: human chromosome 14
cytogenetic location: 14q32.13
expressed in: tibialis anterior muscle

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

See also
References
Further reading
External links

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene.

Kallistatin consists of three folded ß segments and eight helical structures and contains two functional domains, an active site and a heparin-binding site.

Excerpted from Wikipedia’s “SERPINA4” article, available under the CC BY-SA 4.0 licence.