SERPINB1
Sign in to saveAlso known as EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2
Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.
Gene data
SERPINB1- Name
- serpin family B member 1
- Type
- protein-coding
- Position
- 2,832,332–2,842,035 (−)
- Aliases
- EI, ELANH2, HEL-S-27, HEL57, LEI, M/NEI, MNEI, PI-2, PI2
- Ensembl
- ENSG00000021355
- RefSeq RNA
- NM_030666.4, NR_073111.2, NR_073112.2, XM_011514333.2, XM_011514334.3
- RefSeq protein
- NP_109591.1, XP_011512635.1, XP_011512636.1, XP_011512637.1, XP_047274225.1
The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
serpin family B member 1
- Symbol
- SERPINB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:2,832,332-2,842,035
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 1HLE.png
Show 5 more facts
- HomoloGene ID
- 133768
- exact match
- identifiers.org/ncbigene/1992
- genomic end
- 2841959
- genomic start
- 2832566
- cytogenetic location
- 6p25.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- See also
- References
- Further reading
- External links
Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.
MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.