SERPINB4
Sign in to saveAlso known as LEUPIN, PI11, SCCA-2, SCCA1, SCCA2, serpin family B member 4
Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene.
Gene data
SERPINB4- Name
- serpin family B member 4
- Type
- protein-coding
- Position
- 63,637,259–63,644,263 (−)
- Aliases
- LEUPIN, PI11, SCCA-2, SCCA1, SCCA2
- Ensembl
- ENSG00000206073
- RefSeq RNA
- NM_002974.4, NM_175041.2, XM_011526138.2, XM_054318968.1
- RefSeq protein
- NP_002965.1, NP_778206.1, XP_011524440.1, XP_054174943.1
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
serpin family B member 4
- Symbol
- SERPINB4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:63,637,259-63,644,263
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Serpin B4 is a protein that in humans is encoded by the SERPINB4 gene.
==See also== Serpin
Excerpted from Wikipedia’s “SERPINB4” article, available under the CC BY-SA 4.0 licence.