Also known as GCL, grancalcin
Grancalcin is a protein that in humans is encoded by the GCA gene.
Gene data
GCA- Name
- grancalcin
- Type
- protein-coding
- Aliases
- GCL
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016].
via MyGene.info
Gene · Ensembl
grancalcin
- Symbol
- GCA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:162,318,839-162,388,536
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein GCA PDB 1f4o.png
Show 5 more facts
- HomoloGene ID
- 22702
- exact match
- identifiers.org/ncbigene/25801
- genomic end
- 163228105
- genomic start
- 163175350
- cytogenetic location
- 2q24.2
Sources (4)
via Wikidata · CC0
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Article
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- References
- Further reading
Grancalcin is a protein that in humans is encoded by the GCA gene.
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.