glycomics
Sign in to saveGlycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects. Glycomics "is the systematic study of all glycan structures of a given cell type or organism" and is a subset of glycobiology. The term glycomics is derived from the chemical prefix for sweetness or a sugar, "glyco-", and was formed to follow the omics naming convention established by genomics (which deals with genes) and proteomics (which deals with proteins).
Research
7,284 papers- High sensitivity glycomics in biomedicine.Mass spectrometry reviews · 2022
- Glycomics, Glycoproteomics, and Glycogenomics: An Inter-Taxa Evolutionary Perspective.Molecular & cellular proteomics : MCP · 2021
- MS-based glycomics and glycoproteomics methods enabling isomeric characterization.Mass spectrometry reviews · 2023
- [Applications of chromatography in glycomics].Se pu = Chinese journal of chromatography · 2024
- Novel methods in glycomics: a 2019 update.Expert review of proteomics · 2020
via PubMed
~9 min read
Article
12 sectionsContents
- Challenges
- Importance
- Tools used
- High-resolution mass spectrometry (MS) and high-performance liquid chromatography (HPLC)
- Multiple Reaction Monitoring (MRM)
- Arrays
- Metabolic and covalent labeling of glycans
- Tools for glycoproteins
- Software and databases
- See also
- References
- External links
Glycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects. Glycomics "is the systematic study of all glycan structures of a given cell type or organism" and is a subset of glycobiology. The term glycomics is derived from the chemical prefix for sweetness or a sugar, "glyco-", and was formed to follow the omics naming convention established by genomics (which deals with genes) and proteomics (which deals with proteins).
== Challenges == The complexity of sugars: regarding their structures, they are not linear instead they are highly branched. Moreover, glycans can be modified (modified sugars), this increases its complexity. Complex biosynthetic pathways for glycans. Usually glycans are found either bound to protein (glycoprotein) or conjugated with lipids (glycolipids). Unlike genomes, glycans are highly dynamic.