epigenomics
Sign in to saveEpigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell. Epigenetic modifications are reversible modifications on a cell's DNA or histones that affect gene expression without altering the DNA sequence. Epigenomic maintenance is a continuous process and plays an important role in stability of eukaryotic genomes by taking part in crucial biological mechanisms like DNA repair. Plant flavones are said to be inhibitin
Research
32,738 papers- Pharmaco-epigenomics: On the Road of Translation Medicine.Advances in experimental medicine and biology · 2019
- Understanding epigenomics based on the rice model.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020
- 4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling.Current opinion in genetics & development · 2023
- The gymnastics of epigenomics in rice.Plant cell reports · 2018
- From profiles to function in epigenomics.Nature reviews. Genetics · 2017
via PubMed
~25 min read
Article
19 sectionsContents
- Epigenetics
- DNA methylation
- Histone modification
- Relation to other genomic fields
- Methods
- Histone modification assays
- ChIP-Chip and ChIP-Seq
- DNA methylation assays
- Restriction endonuclease based methods
- Non genome-wide approaches
- Genome wide approaches
- Bisulfite sequencing
- Chromatin accessibility assays
- Direct detection
- Theoretical modeling approaches
- See also
- Notes
- References
- Further reading
Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell. Epigenetic modifications are reversible modifications on a cell's DNA or histones that affect gene expression without altering the DNA sequence. Epigenomic maintenance is a continuous process and plays an important role in stability of eukaryotic genomes by taking part in crucial biological mechanisms like DNA repair. Plant flavones are said to be inhibiting epigenomic marks that cause cancers. Two of the most characterized epigenetic modifications are DNA methylation and histone modification. Epigenetic modifications play an important role in gene expression and regulation, and are involved in numerous cellular processes such as in differentiation/development and tumorigenesis. The study of epigenetics on a global level has been made possible only recently through the adaptation of genomic high-throughput assays.
==Epigenetics==