MCAM
Sign in to saveAlso known as CD146, MUC18, melanoma cell adhesion molecule, HEMCAM, METCAM, MelCAM
CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.
In the Vinony graph
Within Vinony's link graph, MCAM is referenced by 416 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 6 Wikipedia language editions.
Gene data
MCAM- Name
- melanoma cell adhesion molecule
- Type
- protein-coding
- Position
- 119,307,972–119,321,521 (−)
- Aliases
- CD146, HEMCAM, METCAM, MUC18, MelCAM
- Ensembl
- ENSG00000076706
- RefSeq RNA
- NM_006500.3, XM_017017759.3, XM_017017760.3, XM_017017761.3, XM_017017762.3
- RefSeq protein
- NP_006491.2, XP_016873248.1, XP_016873249.1, XP_016873250.1, XP_016873251.1
Involved in glomerular filtration and vascular wound healing. Acts upstream of or within angiogenesis. Located in external side of plasma membrane. Biomarker of chronic obstructive pulmonary disease and uveal melanoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
melanoma cell adhesion molecule
- Symbol
- MCAM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:119,307,972-119,321,521
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 4742
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4162
- genomic end
- 119192231
- genomic start
- 119179241
- chromosome
- human chromosome 11
- cytogenetic location
- 11q23.3
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Function
- Relevance in cancer
- References
- Further reading
- External links
CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.
== Function ==
Excerpted from Wikipedia’s “MCAM” article, available under the CC BY-SA 4.0 licence.