ADAM10
Sign in to saveAlso known as AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz, CDw156
A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c, is a protein that in humans is encoded by the ADAM10 gene.
Gene data
ADAM10- Name
- ADAM metallopeptidase domain 10
- Type
- protein-coding
- Position
- 58,588,809–58,749,871 (−)
- Aliases
- AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz
- Ensembl
- ENSG00000137845
- RefSeq RNA
- NM_001110.4, NM_001320570.2
- RefSeq protein
- NP_001101.1, NP_001307499.1
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ADAM metallopeptidase domain 10
- Symbol
- ADAM10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:58,588,809-58,749,871
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ADAM10 PDB 2ao7.png
Show 8 more facts
- HomoloGene ID
- 865
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/102
- genomic end
- 58749791
- genomic start
- 58588809
- cytogenetic location
- 15q21.3
- chromosome
- human chromosome 15
- Commons category
- ADAM10
via Wikidata · CC0
~7 min read
Encyclopedic overview
12 sectionsContents
- Function
- Structure
- Catalytic mechanism
- Clinical significance
- Brain diseases
- Malaria
- Cancer
- Breast cancer
- See also
- References
- Further reading
- External links
A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c, is a protein that in humans is encoded by the ADAM10 gene.
== Function ==
Excerpted from Wikipedia’s “ADAM10” article, available under the CC BY-SA 4.0 licence.