DNAH1
Sign in to saveAlso known as DNAHC1, HDHC7, HL-11, HL11, HSRF-1, XLHSRF-1, dynein axonemal heavy chain 1, SPGF18
Dynein axonemal heavy chain 1 is a protein that in humans is encoded by the DNAH1 gene.
Gene data
DNAH1- Name
- dynein axonemal heavy chain 1
- Type
- protein-coding
- Position
- 52,316,319–52,400,492 (+)
- Aliases
- CILD37, DNAHC1, HDHC7, HL-11, HL11, HSRF-1, SPGF18, XLHSRF-1
- Ensembl
- ENSG00000114841
- RefSeq RNA
- NM_015512.5, XM_017006129.2, XM_017006130.2, XM_017006131.2
- RefSeq protein
- NP_056327.4, XP_016861618.1, XP_016861619.1, XP_016861620.1
This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dynein axonemal heavy chain 1
- Symbol
- DNAH1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:52,316,319-52,400,492
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 67131
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/25981
- chromosome
- human chromosome 3
- genomic start
- 52350335
- genomic end
- 52400492
- cytogenetic location
- 3p21.1
- genetic association
- asthenozoospermia
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Dynein axonemal heavy chain 1 is a protein that in humans is encoded by the DNAH1 gene.
==Function==
Excerpted from Wikipedia’s “DNAH1” article, available under the CC BY-SA 4.0 licence.