STAT2
Sign in to saveAlso known as ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human is only 68%.
Gene data
STAT2- Name
- signal transducer and activator of transcription 2
- Type
- protein-coding
- Position
- 56,341,597–56,360,274 (−)
- Aliases
- IMD44, ISGF-3, P113, PTORCH3, STAT113
- Ensembl
- ENSG00000170581
- RefSeq RNA
- NM_001385110.1, NM_001385111.1, NM_001385113.1, NM_001385114.1, NM_001385115.1
- RefSeq protein
- NP_001372039.1, NP_001372040.1, NP_001372042.1, NP_001372043.1, NP_001372044.1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
signal transducer and activator of transcription 2
- Symbol
- STAT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:56,338,356-56,360,283
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 3952
- exact match
- identifiers.org/ncbigene/6773
- genomic end
- 56360167
- genomic start
- 56735381
- cytogenetic location
- 12q13.3
via Wikidata · CC0
~7 min read
Article
8 sectionsContents
- Function
- Interactions
- STAT2 deficiency
- Knockout mice
- Human autosomal recessive (AR) STAT2 deficiency
- References
- Further reading
- External links
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human is only 68%.
== Function ==