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GeneQ18053565· pop 5· linked from 814 articles

RFX6

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Also known as MTCHRS, MTFS, RFXDC1, dJ955L16.1, regulatory factor X6

Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.

Gene data

RFX6
Name
regulatory factor X6
Type
protein-coding
Position
116,877,212–116,933,069 (+)
Aliases
MTCHRS, MTFS, RFXDC1, dJ955L16.1
Ensembl
ENSG00000185002
RefSeq RNA
NM_173560.4, XM_011535589.2, XM_017010477.2, XM_054354646.1, XM_054354647.1
RefSeq protein
NP_775831.2, XP_011533891.1, XP_016865966.1, XP_054210621.1, XP_054210622.1

The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010].

Gene Ontology

Pathways

Maturity onset diabetes of the young - Homo sapiens (human)Developmental BiologyRegulation of beta-cell developmentRegulation of gene expression in beta cells

via MyGene.info

Gene · Ensembl

regulatory factor X6

Symbol
RFX6
Biotype
Protein coding
Organism
Homo sapiens
Location
6:116,877,212-116,933,069
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
18318
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/222546
genomic end
116932161
genomic start
117198375
chromosome
human chromosome 6
cytogenetic location
6q22.1
Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections
Contents
  • Function
  • Clinical significance
  • References
  • Further reading

Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.

== Function ==

Excerpted from Wikipedia’s “RFX6” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0