TNFAIP6

Also known as TSG-6, TSG6, TNF alpha induced protein 6

Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans is encoded by the TNFAIP6 (tumor necrosis factor, alpha-induced protein 6) gene.

Gene data

TNFAIP6

Name: TNF alpha induced protein 6
Type: protein-coding
Position: 151,357,592–151,380,046 (+)
Aliases: TSG-6, TSG6
Ensembl: ENSG00000123610
RefSeq RNA: NM_007115.4, XM_047445635.1, XM_054343598.1
RefSeq protein: NP_009046.2, XP_047301591.1, XP_054199573.1

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010].