NUDT4
Sign in to saveAlso known as DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, nudix hydrolase 4, DIPP-2B, NUDT4B
Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.
In the Vinony graph
Within Vinony's link graph, NUDT4 is referenced by 2 other articles, and connects out to Q180686, human chromosome 12 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 12 and Nudix hydrolases.
Its subject is documented across 6 Wikipedia language editions.
Gene data
NUDT4- Name
- nudix hydrolase 4
- Type
- protein-coding
- Position
- 93,377,883–93,410,297 (+)
- Aliases
- DIPP-2B, DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P
- Ensembl
- ENSG00000173598
- RefSeq RNA
- NM_001301022.2, NM_001301023.2, NM_001301024.2, NM_019094.6, NM_199040.4
- RefSeq protein
- NP_001287951.1, NP_001287952.1, NP_001287953.1, NP_061967.3, NP_950241.1
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
nudix hydrolase 4
- Symbol
- NUDT4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:93,377,883-93,410,297
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NUDT4 PDB 2duk.png
Show 5 more facts
- HomoloGene ID
- 41726
- exact match
- identifiers.org/ncbigene/11163
- genomic start
- 93771659
- genomic end
- 93797024
- cytogenetic location
- 12q22
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.
Excerpted from Wikipedia’s “NUDT4” article, available under the CC BY-SA 4.0 licence.