English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18055229· pop 5· linked from 2 articles

ST8SIA6

Sign in to save

Also known as SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.

In the Vinony graph

Within Vinony's link graph, ST8SIA6 is referenced by 2 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 10.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ST8SIA6

Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Type: protein-coding
Position: 17,315,416–17,454,681 (−)
Aliases: SIA8F, SIAT8-F, SIAT8F, ST8SIA-VI, ST8SiaVI
Ensembl: ENSG00000148488
RefSeq RNA: NM_001004470.3, NM_001345961.2, NR_144322.2, XM_017016174.2, XM_024447977.2
RefSeq protein: NP_001004470.1, NP_001332890.1, XP_016871663.1, XP_024303745.1, XP_024303746.1

This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].

Gene Ontology

Biological process

ganglioside biosynthetic process ganglioside biosynthetic process N-glycan processing protein O-linked glycosylation glycoprotein metabolic process glycoprotein metabolic process glycoprotein biosynthetic process glycolipid biosynthetic process

Molecular function

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity sialyltransferase activity sialyltransferase activity

Cellular component

Golgi membrane Golgi membrane

Pathways

Metabolism of proteins Sialic acid metabolism Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Asparagine N-linked glycosylation Synthesis of substrates in N-glycan biosythesis Post-translational protein modification Transport to the Golgi and subsequent modification N-glycan antennae elongation in the medial/trans-Golgi N-Glycan antennae elongation

via MyGene.info

Gene · Ensembl

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

Symbol: ST8SIA6
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:17,315,416-17,454,681
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 17112
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/338596
genomic end: 17454595
genomic start: 17315421
chromosome: human chromosome 10
cytogenetic location: 10p12.33
expressed in: white blood cell

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene.

==Function==

Excerpted from Wikipedia’s “ST8SIA6” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 10