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GeneQ18040983· pop 5· linked from 410 articles

DPM3

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Also known as CDG1O, dolichyl-phosphate mannosyltransferase subunit 3, dolichyl-phosphate mannosyltransferase subunit 3, regulatory, MDDGB15, MDDGC15

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

Gene data

DPM3
Name
dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Type
protein-coding
Position
155,138,457–155,140,595 (−)
Aliases
CDG1O, MDDGB15, MDDGC15
Ensembl
ENSG00000179085
RefSeq RNA
NM_018973.4, NM_153741.2, XM_017001498.2, XM_054337104.1
RefSeq protein
NP_061846.2, NP_714963.1, XP_016856987.1, XP_054193079.1

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

N-Glycan biosynthesis - Homo sapiens (human)Synthesis of dolichyl-phosphate mannosePost-translational modification: synthesis of GPI-anchored proteinsDiseaseDiseases of glycosylationMetabolism of proteinsBiosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinAsparagine N-linked glycosylationSynthesis of substrates in N-glycan biosythesisDefective DPM1 causes DPM1-CDG

via MyGene.info

Gene · Ensembl

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

Symbol
DPM3
Biotype
Protein coding
Organism
Homo sapiens
Location
1:155,138,457-155,140,595
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 7 more facts
HomoloGene ID
17810
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/54344
chromosome
human chromosome 1
genomic start
155112367
genomic end
155113071
cytogenetic location
1q22
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Function
  • Clinical significance
  • References
  • Further reading
  • External links

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

== Function ==

Excerpted from Wikipedia’s “DPM3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0