English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ17917730· pop 6· linked from 4 articles

EXTL3

Sign in to save

Also known as BOTV, EXTL1L, EXTR1, REGR, RPR, exostosin like glycosyltransferase 3, ISDNA

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to EXTL3, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 6 Wikipedia language editions.

Gene data

EXTL3

Name: exostosin like glycosyltransferase 3
Type: protein-coding
Position: 28,600,469–28,756,561 (+)
Aliases: BOTV, EXTL1L, EXTR1, ISDNA, REGR, RPR
Ensembl: ENSG00000012232
RefSeq RNA: NM_001437797.1, NM_001438399.1, NM_001438400.1, NM_001438401.1, NM_001438402.1
RefSeq protein: NP_001424726.1, NP_001425328.1, NP_001425329.1, NP_001425330.1, NP_001425331.1

This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012].

Gene Ontology

Biological process

glycoprotein biosynthetic process positive regulation of keratinocyte proliferation positive regulation of keratinocyte proliferation heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of cell growth negative regulation of keratinocyte differentiation

Molecular function

magnesium ion binding glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity protein binding acetylglucosaminyltransferase activity protein-hormone receptor activity protein-hormone receptor activity protein-hormone receptor activity

Cellular component

Golgi membrane nucleus nucleus endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum membrane Golgi apparatus Golgi apparatus

Pathways

Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human)Metabolism Glycosaminoglycan metabolism Heparan sulfate/heparin (HS-GAG) metabolism HS-GAG biosynthesis Cellular responses to stress XBP1(S) activates chaperone genes IRE1alpha activates chaperones Unfolded Protein Response (UPR)Metabolism of carbohydrates and carbohydrate derivatives

via MyGene.info

Gene · Ensembl

exostosin like glycosyltransferase 3

Symbol: EXTL3
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:28,600,469-28,756,561
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 1103
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2137
genomic end: 28756561
genomic start: 28457986
chromosome: human chromosome 8
cytogenetic location: 8p21.1

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.

==References==

Excerpted from Wikipedia’s “EXTL3” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 8