GNL3

Also known as C77032, E2IG3, NNP47, NS, G protein nucleolar 3

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. It is found within the nucleolus that binds p53. Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. It is a marker for many stem cells and cancer cells.

In the Vinony graph

Within Vinony's link graph, GNL3 is referenced by 6 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Human genes.

Its subject is documented across 6 Wikipedia language editions.

Gene data

GNL3

Name: G protein nucleolar 3
Type: protein-coding
Position: 52,681,156–52,696,160 (+)
Aliases: C77032, E2IG3, NNP47, NS, Nug1
Ensembl: ENSG00000163938
RefSeq RNA: NM_014366.5, NM_206825.2, NM_206826.1
RefSeq protein: NP_055181.3, NP_996561.1, NP_996562.1

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].