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CXCL7
Sign in to saveAlso known as neutrophil-activating peptide 2, CXC chemokine ligand 7, MDGF, leukocyte-derived growth factor, small inducible cytokine B7, C-X-C motif chemokine 7, platelet basic protein, thrombocidin 1
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Protein · UniProt
Platelet basic protein
- Gene
- PPBP
- Organism
- Homo sapiens (Human)
- Length
- 128 aa
- Molecular mass
- 13,894 Da
- Evidence
- 1: Evidence at protein level
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitiz…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
7 registered- PHASE2COMPLETEDRAPA-201 T Cell Therapy for Relapsed, Refractory Multiple MyelomaRapa Therapeutics LLC · NCT04176380
- PHASE1/PHASE2TERMINATEDTh1/Tc1 Immunotherapy Following Stem Cell Transplantation in Multiple MyelomaNational Cancer Institute (NCI) · NCT01239368
- PHASE1/PHASE2RECRUITINGRAPA-201 Therapy of Solid TumorsRapa Therapeutics LLC · NCT05144698
- PHASE1COMPLETEDStem Cell Transplant With Th2/Tc2 Cells to Treat Advanced Breast CancerNational Cancer Institute (NCI) · NCT00079625
- PHASE2NOT_YET_RECRUITINGPhase 2b of RAPA-201 Cell Therapy in Post-PD-(L)-1 MelanomaRapa Therapeutics LLC · NCT06708455
- NACOMPLETEDSunitinib Malate in Treating Patients With Kidney CancerCentre Antoine Lacassagne · NCT00943839
Wikidata facts
- Instance of
- protein
Show 3 more facts
- molecular function
- protein binding
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P02775
Sources (4)
via Wikidata · CC0