GP1BA

Name

glycoprotein Ib platelet subunit alpha

Type

protein-coding

Aliases

BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, GPIbalpha, HPA-2

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013].

via MyGene.info

Gene · Ensembl

glycoprotein Ib platelet subunit alpha

Symbol

GP1BA

Biotype

Protein coding

Organism

Homo sapiens

Location

17:4,932,261-4,935,023

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein GP1BA PDB 1gwb.png

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