SELPLG

Also known as CD162, CLA, PSGL-1, PSGL1, selectin P ligand

protein-coding gene in the species Homo sapiens

Gene data

SELPLG

Name: selectin P ligand
Type: protein-coding
Position: 108,620,413–108,633,894 (−)
Aliases: CD162, CLA, PSGL-1, PSGL1
Ensembl: ENSG00000110876
RefSeq RNA: NM_001206609.2, NM_003006.4
RefSeq protein: NP_001193538.1, NP_002997.2

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].