Selectin L
Sign in to saveAlso known as CD62 antigen-like family member L, leukocyte-endothelial cell adhesion molecule 1, TQ1, gp90-MEL, SELL, pln homing receptor, LAM-1, leukocyte surface antigen Leu-8
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in humans by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant. L-selectin plays an important role in both the innate and adaptive immune responses by facilitating leukocyte-endothelial cell adhesion events. These tethering interactions are essential for the trafficking of monocytes and neutrophils into inflamed tissue as well as the homing of lym
Protein · UniProt
L-selectin
- Gene
- SELL
- Organism
- Homo sapiens (Human)
- Length
- 372 aa
- Molecular mass
- 42,187 Da
- Evidence
- 1: Evidence at protein level
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
1 registered- COMPLETEDDynamic Changes in the Levels of sCD62L and SPARC in Chronic Myeloid Leukemia Patients During Imatinib TreatmentTanta University · NCT05387330
Wikidata facts
- Instance of
- protein
- Has part
- C-type lectin-like domain
Show 1 more fact
- found in taxon
- Homo sapiens
via Wikidata · CC0
~10 min read
Encyclopedic overview
13 sectionsContents
- Ligands
- Expression
- Function
- Lymphocytes
- Neutrophils and monocytes
- Embryo
- Clinical significance
- Human immunodeficiency virus (HIV)
- Abnormal pregnancy and infertility
- Cancer
- References
- Further reading
- External links
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in humans by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant. L-selectin plays an important role in both the innate and adaptive immune responses by facilitating leukocyte-endothelial cell adhesion events. These tethering interactions are essential for the trafficking of monocytes and neutrophils into inflamed tissue as well as the homing of lymphocytes to secondary lymphoid organs. L-selectin is also expressed by lymphoid primed hematopoietic stem cells and may participate in the migration of these stem cells to the primary lymphoid organs. In addition to its function in the immune response, L-selectin is expressed on embryonic cells and facilitates the attachment of the blastocyst to the endometrial endothelium during human embryo implantation.
L-selectin is composed of multiple structural regions: an N-terminus C-type lectin domain, an adjacent epidermal growth factor-like domain, two consensus repeat units homologous to those found in C3/C4-binding proteins, an extracellular cleavage site, a short transmembrane domain, and a cytoplasmic tail. It is cleaved by ADAM17.
Excerpted from Wikipedia’s “Selectin L” article, available under the CC BY-SA 4.0 licence.