selectin P
Also known as GMP-140, platelet activation dependent granule-external membrane protein, CD62 antigen-like family member P, granulocyte membrane protein, SELP, granule membrane protein 140kDa, PADGEM, platelet alpha-granule membrane protein
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.
Research
17,579 papers- P- and E- selectin in venous thrombosis and non-venous pathologies.Journal of thrombosis and haemostasis : JTH · 2022
- P-selectin glycoprotein ligand-1 in T cells.Current opinion in hematology · 2017
- P-selectin/ PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis.Thrombosis research · 2010
- P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall.Trends in cardiovascular medicine · 2009
- The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study.Frontiers in endocrinology · 2023
via PubMed
~7 min read
Article
10 sectionsContents
- Gene and regulation
- Structure
- Ligand
- Function
- Role in cancer
- As a drug target
- See also
- References
- Further reading
- External links
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.
P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules.