PPHLN1
Sign in to saveAlso known as HSPC232, HSPC206, CR, periphilin 1
Periphilin-1 is a protein that in humans is encoded by the PPHLN1 gene.
Gene data
PPHLN1- Name
- periphilin 1
- Type
- protein-coding
- Position
- 42,238,418–42,459,715 (+)
- Aliases
- CR, HSPC206, HSPC232
- Ensembl
- ENSG00000134283
- RefSeq RNA
- NM_001143787.2, NM_001143788.2, NM_001143789.2, NM_001364822.2, NM_001364823.2
- RefSeq protein
- NP_001137259.1, NP_001137260.1, NP_001137261.1, NP_001351751.1, NP_001351752.1
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
periphilin 1
- Symbol
- PPHLN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:42,238,418-42,459,715
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9533
- exact match
- identifiers.org/ncbigene/51535
- genomic end
- 42853517
- genomic start
- 42632249
- cytogenetic location
- 12q12
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Periphilin-1 is a protein that in humans is encoded by the PPHLN1 gene.
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis.