C3

Name

complement C3

Type

protein-coding

Position

6,677,704–6,730,562 (−)

Aliases

AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p

Ensembl

ENSG00000125730

RefSeq RNA

NM_000064.4

RefSeq protein

NP_000055.2

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015].

via MyGene.info

Gene · Ensembl

complement C3

Symbol

C3

Biotype

Protein coding

Organism

Homo sapiens

Location

19:6,677,704-6,730,562

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein C3 PDB 1c3d.png

via Wikidata · CC0