C2

Name

complement C2

Type

protein-coding

Position

31,897,785–31,945,674 (+)

Aliases

ARMD14, CO2

Ensembl

ENSG00000231543

RefSeq RNA

NM_000063.6, NM_001145903.3, NM_001178063.3, NM_001282457.2, NM_001282458.2

RefSeq protein

NP_000054.2, NP_001139375.1, NP_001171534.1, NP_001269386.1, NP_001269387.1

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009].

via MyGene.info

Gene · Ensembl

complement C2

Symbol

C2

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR6_MHC_QBL_CTG1:3,153,757-3,201,649

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein C2 PDB 2i6q.png

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