C1QA

Also known as complement C1q A chain

Complement C1q subcomponent subunit A is a protein that in humans is encoded by the C1QA gene.

Gene data

C1QA

Name: complement C1q A chain
Type: protein-coding
Aliases: C1QD1

This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

via MyGene.info

Gene · Ensembl

complement C1q A chain

Symbol: C1QA
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:22,635,057-22,640,201
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Complement c1q subcomponent subunit A 1PK6.png

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HomoloGene ID: 7249
exact match: identifiers.org/ncbigene/712
genomic start: 22635077
genomic end: 22639678
cytogenetic location: 1p36.12

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Complement C1q subcomponent subunit A is a protein that in humans is encoded by the C1QA gene.

This gene encodes a major constituent of the human complement system subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.